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Phenotypes

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Projection neuron vulnerability suggests a therapeutic path

Projection neuron vulnerability suggests a therapeutic path

Region- and lineage-specific transcriptomic changes appear to be responsible for the characteristic pathobiology of multiple sclerosis (MS).
A study that used single-nucleus RNA sequencing to assess changes in cell lineages in MS lesions has shed light on the selective cortical neuron damage and glial activation that contribute to the progression of MS lesions.

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